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The dynamics of cholesterol molecules near the surface of protein farnesyltransferase - Computer simulation

Paper ID Volume ID Publish Year Pages File Format Full-Text
14145 1175 2007 4 PDF Available
Title
The dynamics of cholesterol molecules near the surface of protein farnesyltransferase - Computer simulation
Abstract

We have made the molecular dynamics (MD) simulations for the cluster of cholesterols localized near the protein farnesyltransferase (1FT2) at the physiological temperature T = 309.75 K. We have observed that the cholesterol molecules form a lodgment on the surface of protein. Several physical characteristics of the deposited cholesterol cluster have been calculated among those: the mean square displacement, diffusion coefficient, linear and angular velocity autocorrelation function and their Fourier transforms.

Keywords
Protein; Cholesterol; Cholesterol lodgment; Molecular dynamics; Computer simulation
First Page Preview
The dynamics of cholesterol molecules near the surface of protein farnesyltransferase - Computer simulation
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomolecular Engineering - Volume 24, Issue 5, November 2007, Pages 568–571
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering