fulltext.study @t Gmail

Combinatorial biosynthesis of medicinal plant secondary metabolites

Paper ID Volume ID Publish Year Pages File Format Full-Text
14161 1178 2006 15 PDF Available
Title
Combinatorial biosynthesis of medicinal plant secondary metabolites
Abstract

Combinatorial biosynthesis is a new tool in the generation of novel natural products and for the production of rare and expensive natural products. The basic concept is combining metabolic pathways in different organisms on a genetic level. As a consequence heterologous organisms provide precursors from their own primary and secondary metabolism that are metabolised to the desired secondary product due to the expression of foreign genes. In this review we discuss the possibilities and limitations of combining genes from different organisms and the expression of heterologous genes. Major focuses are fundamentals of the genetic work, used expression systems and latest progress in this field. Combinatorial biosynthesis is discussed for important classes of natural products, including alkaloids (vinblastine, vincristine), terpenoids (artemisinin, paclitaxel) and flavonoids. The role and importance of today's used host organisms is critically described, and the latest approaches discussed to give an outlook for future trends and possibilities.

Keywords
Combinatorial biosynthesis; Plant biotechnology; Bioconversion; Paclitaxel; Artemisinin; Carotenoids; Flavonoids; Herbal medicine; Herbals; Nutraceuticals; Biopharmaceuticals; Recombinant protein; Plant
First Page Preview
Combinatorial biosynthesis of medicinal plant secondary metabolites
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomolecular Engineering - Volume 23, Issue 6, December 2006, Pages 265–279
Authors
, , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us