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Novel technology for rapid species-specific detection of Bacillus spores

Paper ID Volume ID Publish Year Pages File Format Full-Text
14181 1180 2006 9 PDF Available
Title
Novel technology for rapid species-specific detection of Bacillus spores
Abstract

There is an urgent need for a small, inexpensive sensor that can rapidly detect bio-warfare agents with high specificity. Bacillus anthracis, the causative agent of anthrax, would be a perilous disease-causing organism in the event of a release. Currently, most anthrax detection research is based on nucleic acid detection, immunoassays and mass spectrometry, with few detection levels reported below 105 spores. Here, we show the ability to distinguish Bacillus spores to a level approaching 103 spores, below the reported median infectious dose of B. anthracis, using pyrolysis—micromachined differential mobility spectrometry and novel pattern recognition algorithms that combine lead cluster mapping with genetic algorithms.

Keywords
Differential mobility spectrometry; Bacillus spore detection; Genetic algorithms; Adaptive pattern recognition
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomolecular Engineering - Volume 23, Issues 2–3, June 2006, Pages 119–127
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us