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Nanotechnology for the delivery of phytochemicals in cancer therapy

Paper ID Volume ID Publish Year Pages File Format Full-Text
14188 1187 2016 11 PDF Available
Title
Nanotechnology for the delivery of phytochemicals in cancer therapy
Abstract

The aim of this review is to summarize advances that have been made in the delivery of phytochemicals for cancer therapy by the use of nanotechnology. Over recent decades, much research effort has been invested in developing phytochemicals as cancer therapeutic agents. However, several impediments to their wide spread use as drugs still have to be overcome. Among these are low solubility, poor penetration into cells, high hepatic disposition, and narrow therapeutic index. Rapid clearance or uptake by normal tissues and wide tissue distribution result in low drug accumulation in the target tumor sites can result in undesired drug exposure in normal tissues. Association with or encapsulation in nanoscale drug carriers is a potential strategy to address these problems. This review discussed lessons learned on the use of nanotechnology for delivery of phytochemicals that been tested in clinical trials or are moving towards the clinic.

Keywords
Phytochemicals; Cancer therapy; Modification of phytochemicals; Drug delivery system
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 34, Issue 4, July–August 2016, Pages 343–353
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us