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Stem cells and injectable hydrogels: Synergistic therapeutics in myocardial repair ☆

Paper ID Volume ID Publish Year Pages File Format Full-Text
14190 1187 2016 18 PDF Available
Title
Stem cells and injectable hydrogels: Synergistic therapeutics in myocardial repair ☆
Abstract

One of the major problems in the treatment of cardiovascular diseases is the inability of myocardium to self-regenerate. Current therapies are unable to restore the heart's function after myocardial infarction. Myocardial tissue engineering is potentially a key approach to regenerate damaged heart muscle. Myocardial patches are applied surgically, whereas injectable hydrogels provide effective minimally invasive approaches to recover functional myocardium. These hydrogels are easily administered and can be either cell free or loaded with bioactive agents and/or cardiac stem cells, which may apply paracrine effects. The aim of this review is to investigate the advantages and disadvantages of injectable stem cell-laden hydrogels and highlight their potential applications for myocardium repair.

Keywords
Myocardial tissue engineering; Injectable hydrogel; Stem cell transplantation; Infarction; Regeneration
First Page Preview
Stem cells and injectable hydrogels: Synergistic therapeutics in myocardial repair ☆
Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 34, Issue 4, July–August 2016, Pages 362–379
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering