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Portable microfluidic and smartphone-based devices for monitoring of cardiovascular diseases at the point of care

Paper ID Volume ID Publish Year Pages File Format Full-Text
14207 1188 2016 16 PDF Available
Title
Portable microfluidic and smartphone-based devices for monitoring of cardiovascular diseases at the point of care
Abstract

Cardiovascular diseases (CVDs) are the main causes of morbidity and mortality in the world where about 4 in every 5 CVD deaths happen in low- and middle-income countries (LMICs). Most CVDs are preventable and curable, which is largely dependent on timely and effective interventions, including diagnosis, prognosis and therapeutic monitoring. However, these interventions are high-cost in high income countries and are usually lacking in LMICs. Thanks to the rapid development of microfluidics and nanotechnology, lots of portable analytical devices are developed for detection of CVDs at the point-of-care (POC). In the meantime, smartphone, as a versatile and powerful handheld tool, has been employed not only as a reader for microfluidic assays, but also as an analyzer for physiological indexes. In this review, we present a comprehensive introduction of the current status and potential development direction on POC diagnostics for CVDs. First of all, we introduce some main facts about CVDs and their standard diagnostic procedures and methods. Second, we discuss about both commercially available POC devices and developed prototypes for detection of CVDs via immunoassays. Subsequently, we report the advances in smartphone-based readout for microfluidic assays. Finally, we present some examples using smartphone, individually or combined with other components or devices, for CVD monitoring. We envision an integrated smartphone-based system capable of functioning blood tests, disease examination, and imaging will come in the future.

Keywords
Cardiovascular diseases (CVDs); Point-of-care testing (POCT); Microfluidics; Nanotechnology; Paper-based diagnostics; Mobile health
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Portable microfluidic and smartphone-based devices for monitoring of cardiovascular diseases at the point of care
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 34, Issue 3, May–June 2016, Pages 305–320
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us