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BBB-targeting, protein-based nanomedicines for drug and nucleic acid delivery to the CNS

Paper ID Volume ID Publish Year Pages File Format Full-Text
14213 1189 2015 11 PDF Available
Title
BBB-targeting, protein-based nanomedicines for drug and nucleic acid delivery to the CNS
Abstract

The increasing incidence of diseases affecting the central nervous system (CNS) demands the urgent development of efficient drugs. While many of these medicines are already available, the Blood Brain Barrier and to a lesser extent, the Blood Spinal Cord Barrier pose physical and biological limitations to their diffusion to reach target tissues. Therefore, efforts are needed not only to address drug development but specially to design suitable vehicles for delivery into the CNS through systemic administration. In the context of the functional and structural versatility of proteins, recent advances in their biological fabrication and a better comprehension of the physiology of the CNS offer a plethora of opportunities for the construction and tailoring of plain nanoconjugates and of more complex nanosized vehicles able to cross these barriers. We revise here how the engineering of functional proteins offers drug delivery tools for specific CNS diseases and more transversally, how proteins can be engineered into smart nanoparticles or ‘artificial viruses’ to afford therapeutic requirements through alternative administration routes.

Keywords
Nanoparticles; BBB; Protein engineering; Recombinant proteins; Artificial viruses; Drug delivery; Gene therapy
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 33, Issue 2, March–April 2015, Pages 277–287
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us