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Drug nano-reservoirs synthesized using layer-by-layer technologies

Paper ID Volume ID Publish Year Pages File Format Full-Text
14225 1194 2015 17 PDF Available
Title
Drug nano-reservoirs synthesized using layer-by-layer technologies
Abstract

The pharmaceutical industry has been able to tackle the emergence of new microorganisms and diseases by synthesizing new specialized drugs to counter them. Their administration must ensure that a drug is effectively encapsulated and protected until it reaches its target, and that it is released in a controlled way. Herein, the potential of layer-by-layer (LbL) structures to act as drug reservoirs is presented with an emphasis to “nano”-devices of various geometries, from planar coatings to fibers and capsules. The inherent versatile nature of this technique allows producing carriers resorting to distinct classes of materials, variable geometry and customized release profiles that fit within adequate criteria required for disease treatment or for novel applications in the tissue engineering field. The production methods of LbL reservoirs are varied and allow for different kinds of molecules to be incorporated, such as antibiotics, growth factors and biosensing substances, not limited to water-soluble molecules but including hydrophobic drugs. We will also debate the future of LbL in the pharmaceutical industry. Currently, multilayered structures are yet to be covered by the regulatory guidelines that govern the fabrication of nanotechnology products. However, as they stand now, LbL nanodevices have already shown usefulness for antifouling applications, gene therapy, nanovaccines and the formation of de novo tissues.

Keywords
Layer-by-layer; Drug delivery; Tissue engineering; Biomaterials; Nanofilms; Nanofibers; Nanocapsules; Nanodrugs; Nanomedicine; Stimuli-responsive nanobiomaterials
First Page Preview
Drug nano-reservoirs synthesized using layer-by-layer technologies
Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 33, Issue 6, Part 3, 1 November 2015, Pages 1310–1326
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering