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State of the art, challenges and perspectives in the design of nitric oxide-releasing polymeric nanomaterials for biomedical applications

Paper ID Volume ID Publish Year Pages File Format Full-Text
14229 1194 2015 10 PDF Available
Title
State of the art, challenges and perspectives in the design of nitric oxide-releasing polymeric nanomaterials for biomedical applications
Abstract

•Polymeric nanomaterials are able to mimic endogenous production of nitric oxide•Combination of nitric oxide and nanocarriers is an efficient approach for biomedical applications•The precise control of NO spatiotemporal delivery represents a challenge to the scientific community

Recently, an increasing number of publications have demonstrated the importance of the small molecule nitric oxide (NO) in several physiological and pathophysiological processes. NO acts as a key modulator in cardiovascular, immunological, neurological, and respiratory systems, and deficiencies in the production of NO or its inactivation has been associated with several pathologic conditions, ranging from hypertension to sexual dysfunction. Although the clinical administration of NO is still a challenge owing to its transient chemical nature, the combination of NO and nanocarriers based on biocompatible polymeric scaffolds has emerged as an efficient approach to overcome the difficulties associated with the biomedical administration of NO. Indeed, significant progress has been achieved by designing NO-releasing polymeric nanomaterials able to promote the spatiotemporal generation of physiologically relevant amounts of NO in diverse pharmacological applications. In this review, we summarize the recent advances in the preparation of versatile NO-releasing nanocarriers based on polymeric nanoparticles, dendrimers and micelles. Despite the significant innovative progress achieved using nanomaterials to tailor NO release, certain drawbacks still need to be overcome to successfully translate these research innovations into clinical applications. In this regard, this review discusses the state of the art regarding the preparation of innovative NO-releasing polymeric nanomaterials, their impact in the biological field and the challenges that need to be overcome. We hope to inspire new research in this exciting area based on NO and nanotechnology.

Keywords
Nitric oxide; Polymeric nanoparticles; Micelles; Dendrimers; Drug release; Cancer; Antibacterial; S-nitrosothiols; NONOates
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State of the art, challenges and perspectives in the design of nitric oxide-releasing polymeric nanomaterials for biomedical applications
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 33, Issue 6, Part 3, 1 November 2015, Pages 1370–1379
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us