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Rapid prototyping of microbial cell factories via genome-scale engineering

Paper ID Volume ID Publish Year Pages File Format Full-Text
14236 1195 2015 13 PDF Available
Title
Rapid prototyping of microbial cell factories via genome-scale engineering
Abstract

Advances in reading, writing and editing genetic materials have greatly expanded our ability to reprogram biological systems at the resolution of a single nucleotide and on the scale of a whole genome. Such capacity has greatly accelerated the cycles of design, build and test to engineer microbes for efficient synthesis of fuels, chemicals and drugs. In this review, we summarize the emerging technologies that have been applied, or are potentially useful for genome-scale engineering in microbial systems. We will focus on the development of high-throughput methodologies, which may accelerate the prototyping of microbial cell factories.

Keywords
Genome-scale engineering; Microbial cell factory; Transcriptome engineering; Genome synthesis; Homologous recombination; High-throughput technology
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 33, Issue 7, 15 November 2015, Pages 1420–1432
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us