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A review of advanced oral drug delivery technologies facilitating the protection and absorption of protein and peptide molecules

Paper ID Volume ID Publish Year Pages File Format Full-Text
14248 1196 2014 14 PDF Available
Title
A review of advanced oral drug delivery technologies facilitating the protection and absorption of protein and peptide molecules
Abstract

•Discusses current approaches to overcome GIT absorption barriers for macromolecules•Elaborates on advanced oral macromolecular technologies for clinical application•Critically evaluates oral macromolecule systems developed and in clinical trials•Provides a critical analysis of the inherent pharmacokinetic advancements

The oral delivery of proteins and peptides is a dynamic research field despite the numerous challenges limiting their effective delivery. Successful oral delivery of proteins and peptides requires the accomplishment of three key tasks: protection of the macromolecules from degradation in the gastrointestinal tract (GIT), permeation through the intestinal barrier and absorption of molecules into the systemic circulation. Currently, no clinically useful oral formulations have been developed but several attempts have been made to overcome the challenges of low oral bioavailability resulting from poor absorption, poor permeation and enzymatic degradation of the proteins and peptides in the GIT. Present strategies attempt to provide structural protection of the proteins and peptides and improved absorption through the use of enzyme inhibitors, absorption enhancers, novel polymeric delivery systems and chemical modification. However, each of these technologies has their limitations despite showing positive results. This review attempts to discuss the physical and chemical barriers of the GIT with particular emphasis on the current approaches employed to overcome these barriers, including the evaluation of other non-parenteral routes of protein and peptide delivery. In addition, this review assimilates oral formulation strategies under development and within the clinical trial stage in relation to their benefits and drawbacks with regard to facilitating optimal protection and absorption of proteins and peptides, as well as pertinent future challenges and opportunities governing oral drug delivery.

Keywords
Oral drug delivery; Therapeutic proteins and peptides; Bioavailability; Gastrointestinal barrier; Advanced oral biotechnology
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A review of advanced oral drug delivery technologies facilitating the protection and absorption of protein and peptide molecules
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 32, Issue 7, 15 November 2014, Pages 1269–1282
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us