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Very small photoluminescent gold nanoparticles for multimodality biomedical imaging ☆

Paper ID Volume ID Publish Year Pages File Format Full-Text
14257 1198 2013 7 PDF Available
Title
Very small photoluminescent gold nanoparticles for multimodality biomedical imaging ☆
Abstract

An original synthesis method based on X-ray irradiation produced gold nanoparticles (AuNPs) with two important properties for biomedical research: intense visible photoluminescence and very high accumulation in cancer cells. The nanoparticles, coated with MUA (11-mercaptoundecanoid acid), are very small (1.4 nm diameter); the above two properties are not present for even slightly larger sizes. The small MUA-AuNPs are non-cytotoxic (except for very high concentrations) and do not interfere with cancer cell proliferation. Multimodality imaging using visible light fluorescence and X-ray microscopy is demonstrated by tracing the nanoparticle-loaded tumor cells.

Keywords
Photoluminescence; Au nanoparticles; X-ray imaging; Cellular uptake; Radiation synthesis; Cytotoxicity; Tumor development
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Very small photoluminescent gold nanoparticles for multimodality biomedical imaging ☆
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 31, Issue 3, May–June 2013, Pages 362–368
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us