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Toxicity of inorganic nanomaterials in biomedical imaging

Paper ID Volume ID Publish Year Pages File Format Full-Text
14270 1202 2014 17 PDF Available
Title
Toxicity of inorganic nanomaterials in biomedical imaging
Abstract

Inorganic nanoparticles have shown promising potentials as novel biomedical imaging agents with high sensitivity, high spatial and temporal resolution. To translate the laboratory innovations into clinical applications, their potential toxicities are highly concerned and have to be evaluated comprehensively both in vitro and in vivo before their clinical applications. In this review, we first summarized the in vivo and in vitro toxicities of the representative inorganic nanoparticles used in biomedical imagings. Then we further discuss the origin of nanotoxicity of inorganic nanomaterials, including ROS generation and oxidative stress, chemical instability, chemical composition, the surface modification, dissolution of nanoparticles to release excess free ions of metals, metal redox state, and left-over chemicals from synthesis, etc. We intend to provide the readers a better understanding of the toxicology aspects of inorganic nanomaterials and knowledge for achieving optimized designs of safer inorganic nanomaterials for clinical applications.

Keywords
Medical imaging; Inorganic materials; Nanomedicine; Nanotoxicity; Iron nanoparticles; QDs; Gold nanoparticles; Upconversion nanoparticles
First Page Preview
Toxicity of inorganic nanomaterials in biomedical imaging
Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 32, Issue 4, July–August 2014, Pages 727–743
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering