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Tumor extracellular acidity-activated nanoparticles as drug delivery systems for enhanced cancer therapy

Paper ID Volume ID Publish Year Pages File Format Full-Text
14274 1202 2014 15 PDF Available
Title
Tumor extracellular acidity-activated nanoparticles as drug delivery systems for enhanced cancer therapy
Abstract

pH-responsive nanoparticles (NPs) are currently under intense development as drug delivery systems for cancer therapy. Among various pH-responsiveness, NPs that are designed to target slightly acidic extracellular pH environment (pHe) of solid tumors provide a new paradigm of tumor targeted drug delivery. Compared to conventional specific surface targeting approaches, the pHe-targeting strategy is considered to be more general due to the common occurrence of acidic microenvironment in solid tumors. This review mainly focuses on the design and applications of pHe-activated NPs, with special emphasis on pHe-activated surface charge reversal NPs, for drug and siRNA delivery to tumors. The novel development of NPs described here offers great potential for achieving better therapeutic effects in cancer treatment.

Keywords
Nanoparticles; Cancer therapy; Drug delivery; Surface charge reversal; Tumor extracellular acidity responsive
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Tumor extracellular acidity-activated nanoparticles as drug delivery systems for enhanced cancer therapy
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 32, Issue 4, July–August 2014, Pages 789–803
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us