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Design, preparation and application of nucleic acid delivery carriers

Paper ID Volume ID Publish Year Pages File Format Full-Text
14275 1202 2014 14 PDF Available
Title
Design, preparation and application of nucleic acid delivery carriers
Abstract

Gene delivery vectors must deliver their cargoes into the cytosol or the nucleus, where DNA or siRNA functions in vivo. Therefore it is crucial for the rational design of the nucleic acid delivery carriers. Compared with viral vectors, non-viral vectors have overcome some fatal defections in gene therapy. Whereas the most important issue for the non-viral vectors is the low transfection efficiency, which hinders the progress of non-viral carriers. Sparked by the structures of the virus and understanding of the process of virus infection, various biomimic structures of non-viral carriers were designed and prepared to improve the transfection issues in vitro and in vivo. However, less impressive results are achieved. In this review, we will investigate the evolution of the virus-mimicking carriers of nucleic acids for gene therapy, especially in cancer therapy; explore and discuss the relationship between the structures, materials and functions of the carriers, to provide guidance for establishing safe and highly efficient non-viral carriers for gene therapy.

Keywords
Gene delivery; Non-viral vectors; Liposome; Polymersome; Dendrimersome
First Page Preview
Design, preparation and application of nucleic acid delivery carriers
Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 32, Issue 4, July–August 2014, Pages 804–817
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering