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The transport and mediation mechanisms of the common sugars in Escherichia coli

Paper ID Volume ID Publish Year Pages File Format Full-Text
14295 1205 2014 15 PDF Available
Title
The transport and mediation mechanisms of the common sugars in Escherichia coli
Abstract

Escherichia coli can uptake and utilize many common natural sugars to form biomass or valuable target bio-products. Carbon catabolite repression (CCR) will occur and hamper the efficient production of bio-products if E. coli strains are cultivated in a mixture of sugars containing some preferred sugar, such as glucose. Understanding the transport and metabolism mechanisms of the common and inexpensive sugars in E. coli is important for further improving the efficiency of sugar bioconversion and for reducing industrial fermentation costs using the methods of metabolic engineering, synthetic biology and systems biology. In this review, the transport and mediation mechanisms of glucose, fructose, sucrose, xylose and arabinose are discussed and summarized, and the hierarchical utilization principles of these sugars are elucidated.

Keywords
Escherichia coli; Low-cost sugars; Sugar transport system; Regulation
First Page Preview
The transport and mediation mechanisms of the common sugars in Escherichia coli
Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 32, Issue 5, September–October 2014, Pages 905–919
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering