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Multifaceted applications of nanomaterials in cell engineering and therapy

Paper ID Volume ID Publish Year Pages File Format Full-Text
14329 1209 2013 16 PDF Available
Title
Multifaceted applications of nanomaterials in cell engineering and therapy
Abstract

Nanomaterials with superior physiochemical properties have been rapidly developed and integrated in every aspect of cell engineering and therapy for translating their great promise to clinical success. Here we demonstrate the multifaceted roles played by innovatively-designed nanomaterials in addressing key challenges in cell engineering and therapy such as cell isolation from heterogeneous cell population, cell instruction in vitro to enable desired functionalities, and targeted cell delivery to therapeutic sites for prompting tissue repair. The emerging trends in this interdisciplinary and dynamic field are also highlighted, where the nanomaterial-engineered cells constitute the basis for establishing in vitro disease model; and nanomaterial-based in situ cell engineering are accomplished directly within the native tissue in vivo. We will witness the increasing importance of nanomaterials in revolutionizing the concept and toolset of cell engineering and therapy which will enrich our scientific understanding of diseases and ultimately fulfill the therapeutic demand in clinical medicine.

Keywords
AFM, atomic force microscopy; BacMNP, bacteria-synthesized MNP; BMM, bone marrow‐derived macrophage; BMNC, bone-marrow mononuclear cell; CB, cord blood; DA neurons, dopaminergic neurons; ECM, extracellular matrix; FDA, Food and Drug Administration; FRET,
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 31, Issue 5, September–October 2013, Pages 638–653
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us