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Fiber-based tissue engineering: Progress, challenges, and opportunities

Paper ID Volume ID Publish Year Pages File Format Full-Text
14331 1209 2013 19 PDF Available
Title
Fiber-based tissue engineering: Progress, challenges, and opportunities
Abstract

Tissue engineering aims to improve the function of diseased or damaged organs by creating biological substitutes. To fabricate a functional tissue, the engineered construct should mimic the physiological environment including its structural, topographical, and mechanical properties. Moreover, the construct should facilitate nutrients and oxygen diffusion as well as removal of metabolic waste during tissue regeneration. In the last decade, fiber-based techniques such as weaving, knitting, braiding, as well as electrospinning, and direct writing have emerged as promising platforms for making 3D tissue constructs that can address the abovementioned challenges. Here, we critically review the techniques used to form cell-free and cell-laden fibers and to assemble them into scaffolds. We compare their mechanical properties, morphological features and biological activity. We discuss current challenges and future opportunities of fiber-based tissue engineering (FBTE) for use in research and clinical practice.

► We critically review the techniques used to form cell-free and cell-laden fibers and to assemble them into scaffolds. ► We compare their mechanical properties, morphological features and biological activity. ► We discuss current challenges and future opportunities of fiber-based tissue engineering for use in research and clinical practice.

Keywords
Tissue engineering; Fiber-based techniques; Scaffold fabrication; Cell-laden constructs
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 31, Issue 5, September–October 2013, Pages 669–687
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us