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Generation of tissue constructs for cardiovascular regenerative medicine: From cell procurement to scaffold design

Paper ID Volume ID Publish Year Pages File Format Full-Text
14334 1209 2013 14 PDF Available
Title
Generation of tissue constructs for cardiovascular regenerative medicine: From cell procurement to scaffold design
Abstract

The ability of the human body to naturally recover from coronary heart disease is limited because cardiac cells are terminally differentiated, have low proliferation rates, and low turn-over rates. Cardiovascular tissue engineering offers the potential for production of cardiac tissue ex vivo, but is currently limited by several challenges: (i) Tissue engineering constructs require pure populations of seed cells, (ii) Fabrication of 3-D geometrical structures with features of the same length scales that exist in native tissue is non-trivial, and (iii) Cells require stimulation from the appropriate biological, electrical and mechanical factors. In this review, we summarize the current state of microfluidic techniques for enrichment of subpopulations of cells required for cardiovascular tissue engineering, which offer unique advantages over traditional plating and FACS/MACS-based enrichment. We then summarize modern techniques for producing tissue engineering scaffolds that mimic native cardiac tissue.

Keywords
Cardiovascular tissue engineering; Cell enrichment; Scaffolds; Immunocapture; Hydrogel; Cardiomyocyte; Endothelial progenitor cell; Fibroblast; Microfluidic
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Generation of tissue constructs for cardiovascular regenerative medicine: From cell procurement to scaffold design
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 31, Issue 5, September–October 2013, Pages 722–735
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us