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A new approach in biomimetic synthesis of calcium phosphate coatings using lactic acid–Na lactate buffered body fluid solution

Paper ID Volume ID Publish Year Pages File Format Full-Text
1434 83 2010 7 PDF Available
Title
A new approach in biomimetic synthesis of calcium phosphate coatings using lactic acid–Na lactate buffered body fluid solution
Abstract

The main objective of this study was to investigate calcium phosphate (CaP) coatings on Ti6Al4V substrates by using the biomimetic technique. To this purpose, a new solution was developed to coat CaP on Ti6Al4V alloy substrates. The newly formulated body fluid (Lac-SBF) contained appropriate amounts of sodium lactate (NaL) and lactic acid (HL), as well as all the other ionic constituents of the human blood plasma. The inorganic ion concentrations of the Lac-SBF solutions were identical with those of human blood plasma. The new Lac-SBF solution of this study eliminated the need for using Tris/HCl or Hepes/NaOH buffers. Prior to coating, Ti6Al4V substrates were chemically treated in NaOH and/or NaOH + H2O2 solutions as an alternative route and then heated at 600 °C for 1 h in air. In the previous applications, the Cl− ion concentration was found to be higher than blood plasma 103 mM, which exists in human blood plasma as a result of Tris/HCl which are used to prevent precipitation and to keep the pH level at certain values. In this study, instead of using Tris/HCl, HL/NaL which are generated by human body and do not show any toxic behavior, are used and Cl− concentration was kept at 103 mM value for the first time. The prepared Lac-SBF was shown to have similar concentration to human blood plasma in terms of all inorganic ions for the first time. Solution properties were evaluated by using turbidimeter, pH meter and rheometer. The coatings were characterized using Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and a scratch tester. The obtained results are presented and discussed.

Keywords
Hydroxyapatite; Brushite; Calcium phosphate; Coating; Biomimetic
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A new approach in biomimetic synthesis of calcium phosphate coatings using lactic acid–Na lactate buffered body fluid solution
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 6, Issue 6, June 2010, Pages 2282–2288
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us