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Engineering of transcriptional regulators enhances microbial stress tolerance

Paper ID Volume ID Publish Year Pages File Format Full-Text
14358 1210 2013 6 PDF Available
Title
Engineering of transcriptional regulators enhances microbial stress tolerance
Abstract

Both prokaryotes and eukaryotes have pyramid-shaped hierarchical regulatory networks that control gene transcription, enabling the cell to respond to natural environmental changes. In recent years, manipulation and engineering of transcriptional regulatory proteins and networks have been used to elicit microbial tolerance to industrially relevant stresses. We review the current research on the engineering of regulators that include specific, “middle level”, and global regulators, and native, artificial, and exogenous regulators. With an increasing number of transcriptional regulators identified and characterized, this methodology should prove promising for the improvement of microbial stress tolerance.

Keywords
Stress tolerance; Regulator engineering; Regulators; Global regulator; Sigma factor; Artificial regulator; Zinc finger; Synthetic biology
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 31, Issue 6, 1 November 2013, Pages 986–991
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us