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Serine/threonine phosphatases in socioeconomically important parasitic nematodes—Prospects as novel drug targets?

Paper ID Volume ID Publish Year Pages File Format Full-Text
14363 1213 2011 12 PDF Available
Title
Serine/threonine phosphatases in socioeconomically important parasitic nematodes—Prospects as novel drug targets?
Abstract

Little is known about the fundamental biology of parasitic nematodes (= roundworms) that cause serious diseases, affecting literally billions of animals and humans worldwide. Unlocking the biology of these neglected pathogens using modern technologies will yield crucial and profound knowledge of their molecular biology, and could lead to new treatment and control strategies. Supported by studies in the free-living nematode, Caenorhabditis elegans, some recent investigations have provided improved insights into selected protein phosphatases (PPs) of economically important parasitic nematodes (Strongylida). In the present article, we review this progress and assess the potential of serine/threonine phosphatase (STP) genes and/or their products as targets for new nematocidal drugs. Current information indicates that some small molecules, known to specifically inhibit PPs, might be developed as nematocides. For instance, some cantharidin analogues are known to display exquisite PP-inhibitor activity, which indicates that some of them could be designed and tailored to specifically inhibit selected STPs of nematodes. This information provides prospects for the discovery of an entirely novel class of nematocides, which is of paramount importance, given the serious problems linked to anthelmintic resistance in parasitic nematode populations of livestock, and has the potential to lead to significant biotechnological outcomes.

Keywords
Parasitic nematodes; Drug resistance; New drug targets; Protein phosphatases (PPs); Serine/threonine phosphatases (STPs); Genomics; Bioinformatics; Biotechnology
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Serine/threonine phosphatases in socioeconomically important parasitic nematodes—Prospects as novel drug targets?
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 29, Issue 1, January–February 2011, Pages 28–39
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us