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Comprehension of ECM-Cell dynamics: A prerequisite for tissue regeneration

Paper ID Volume ID Publish Year Pages File Format Full-Text
14423 1219 2010 6 PDF Available
Title
Comprehension of ECM-Cell dynamics: A prerequisite for tissue regeneration
Abstract

Tissue regeneration and cell therapy have an enormous potential in healthcare through the creation of artificial human tissues and organs. The possibility of producing functional replica of tissues and organs can offer a common, solitary solution for various kinds of inflictions. It can also provide an ultimate test model for drug discovery. There exists convincing evidence that if cells are cultured in extra-cellular matrix (ECM) mimicking 3D scaffolds infused with tissue-specific biochemical cues they grow and differentiate to express functionality. However, comprehensive understanding of ECM and its dynamic relation with the growing cells is vital for creating functional tissue models ex vivo. Different medical and non-medical groups all over the world are working towards achieving affordable, user friendly and technically viable solutions for improving our understanding of Cell-ECM dynamics for tissue engineering (TE). Successful TE, an ambitious goal that includes tissue neogenesis in vitro and functional tissue mending (regenerative medicine) in vivo, however involves innumerable challenges. Present review discusses some of the major technical hurdles that hinder the pace of progress in tissue regeneration/engineering (TE).

Keywords
Tissue engineering; ECM mimicking; Scaffold; Cell-free; Amniotic membrane; Small intestine submucosa; Matrigel; Collagen; Hyaluronic acid; Glycosaminoglycans
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 28, Issue 6, November–December 2010, Pages 764–769
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us