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Progress on the transcriptomics of carcinogenic liver flukes of humans—Unique biological and biotechnological prospects

Paper ID Volume ID Publish Year Pages File Format Full-Text
14431 1219 2010 12 PDF Available
Title
Progress on the transcriptomics of carcinogenic liver flukes of humans—Unique biological and biotechnological prospects
Abstract

Liver flukes, such as Clonorchis sinensis and Opisthorchis viverrini, are food-borne parasites that have a major impact on the health of humans and animals, particularly in Asia. However, the impact of C. sinensis and O. viverrini, in particular, is exacerbated in that these parasites can induce a malignant, untreatable cancer (cholangiocarcinoma, CCA) in chronically infected people. As a result, these flukes are classified as Group 1 carcinogens. Despite their substantial socio-economic importance, little is known about these parasites and their relationship with the definitive hosts at the molecular level. Here, we provide a background on these two carcinogenic flukes and review recent progress on characterizing their transcriptomes using next-generation technologies. We also describe the prospects that the transcriptomes of C. sinensis and O. viverrini provide as a resource for future -omic explorations and efforts to develop improved methods of intervention and control against these important pathogens and CCA, leading to biotechnological outcomes.

Keywords
Liver flukes (Opisthorchiidae); Clonorchis sinensis; Opisthorchis viverrini; Carcinogens; Cholangiocarcinoma; Transcriptomics; Bioinformatics
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Progress on the transcriptomics of carcinogenic liver flukes of humans—Unique biological and biotechnological prospects
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 28, Issue 6, November–December 2010, Pages 859–870
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us