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Metabolic reengineering invoked by microbial systems to decontaminate aluminum: Implications for bioremediation technologies

Paper ID Volume ID Publish Year Pages File Format Full-Text
14453 1220 2013 8 PDF Available
Title
Metabolic reengineering invoked by microbial systems to decontaminate aluminum: Implications for bioremediation technologies
Abstract

As our reliance on aluminum (Al) increases, so too does its presence in the environment and living systems. Although generally recognized as safe, its interactions with most living systems have been nefarious. This review presents an overview of the noxious effects of Al and how a subset of microbes can rework their metabolic pathways in order to survive an Al-contaminated environment. For instance, in order to expulse the metal as an insoluble precipitate, Pseudomonas fluorescens shuttles metabolites toward the production of organic acids and lipids that play key roles in chelating, immobilizing and exuding Al. Further, the reconfiguration of metabolic modules enables the microorganism to combat the dearth of iron (Fe) and the excess of reactive oxygen species (ROS) promoted by Al toxicity. While in Rhizobium spp., exopolysaccharides have been invoked to sequester this metal, an ATPase is known to safeguard Anoxybacillus gonensis against the trivalent metal. Hydroxyl, carboxyl and phosphate moieties have also been exploited by microbes to trap Al. Hence, an understanding of the metabolic networks that are operative in microorganisms residing in polluted environments is critical in devising bioremediation technologies aimed at managing metal wastes. Metabolic engineering is essential in elaborating effective biotechnological processes to decontaminate metal-polluted surroundings.

► Aluminum (Al) occurrence, toxicity and the ecosystem ► Adaptation to Al in microbial systems ► Metabolic engineering in Pseudomonas fluorescens ► Bioremediation technologies for waste metal management ► Optimization of bioreactor/biofilter design

Keywords
ACN, aconitase; AGODH, acylating glyoxylate dehydrogenase; FUM, fumarase; G6PDH, glucose-6-phosphate dehydrogenase; ICDH, isocitrate dehydrogenase; ICL, isocitrate lyase; KGDH, alpha-ketoglutarate dehydrogenase; MDH, malate dehydrogenase; ME, malic enzyme
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Metabolic reengineering invoked by microbial systems to decontaminate aluminum: Implications for bioremediation technologies
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 31, Issue 2, March–April 2013, Pages 266–273
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us