fulltext.study @t Gmail

On the functional and structural characterization of hubs in protein–protein interaction networks

Paper ID Volume ID Publish Year Pages File Format Full-Text
14454 1220 2013 13 PDF Available
Title
On the functional and structural characterization of hubs in protein–protein interaction networks
Abstract

A number of interesting issues have been addressed on biological networks about their global and local properties. The connection between the topological properties of proteins in Protein–Protein Interaction (PPI) networks and their biological relevance has been investigated focusing on hubs, i.e. proteins with a large number of interacting partners. We will survey the literature trying to answer the following questions: Do hub proteins have special biological properties? Do they tend to be more essential than non-hub proteins? Are they more evolutionarily conserved? Do they play a central role in modular organization of the protein interaction network? Are there structural properties that characterize hub proteins?

Keywords
Protein–Protein interaction networks; Network topology; Hubs; Protein 3D structure; Evolution; Lethality; Structural disorder
First Page Preview
On the functional and structural characterization of hubs in protein–protein interaction networks
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 31, Issue 2, March–April 2013, Pages 274–286
Authors
, , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us