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Fifteen years of large scale metabolic modeling of yeast: Developments and impacts

Paper ID Volume ID Publish Year Pages File Format Full-Text
14466 1223 2012 10 PDF Available
Title
Fifteen years of large scale metabolic modeling of yeast: Developments and impacts
Abstract

Since the first large-scale reconstruction of the Saccharomyces cerevisiae metabolic network 15 years ago the development of yeast metabolic models has progressed rapidly, resulting in no less than nine different yeast genome-scale metabolic models. Here we review the historical development of large-scale mathematical modeling of yeast metabolism and the growing scope and impact of applications of these models in four different areas: as guide for metabolic engineering and strain improvement, as a tool for biological interpretation and discovery, applications of novel computational framework and for evolutionary studies.

Keywords
Genome-scale metabolic model; Systems biology; Metabolic engineering; Computational algorithms; Evolution
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 30, Issue 5, September–October 2012, Pages 979–988
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us