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Peptide-mediated DNA condensation for non-viral gene therapy

Paper ID Volume ID Publish Year Pages File Format Full-Text
14507 1225 2009 7 PDF Available
Title
Peptide-mediated DNA condensation for non-viral gene therapy
Abstract

The construction of non-viral, virus-like vehicles for gene therapy involves the functionalization of multipartite constructs with nucleic acid-binding, cationic agents. Short basic peptides, alone or as fusion proteins, are appropriate DNA binding and condensing elements, whose incorporation into gene delivery vehicles results in the formation of protein–DNA complexes of appropriate size for cell internalization and intracellular trafficking. We review here the most used cationic peptides for artificial virus construction as well as the recently implemented strategies to control the architecture and biological activities of the resulting nanosized particles.

Keywords
Recombinant drugs; Gene therapy; Protein engineering; Multifunctional proteins; Cationic peptides; DNA binding; Nanoparticles; Artificial viruses
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Peptide-mediated DNA condensation for non-viral gene therapy
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 27, Issue 4, July–August 2009, Pages 432–438
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us