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Advanced in silico analysis of expressed sequence tag (EST) data for parasitic nematodes of major socio-economic importance — Fundamental insights toward biotechnological outcomes

Paper ID Volume ID Publish Year Pages File Format Full-Text
14508 1225 2009 10 PDF Available
Title
Advanced in silico analysis of expressed sequence tag (EST) data for parasitic nematodes of major socio-economic importance — Fundamental insights toward biotechnological outcomes
Abstract

Parasitic nematodes infect humans, other animals and plants, and impose a significant public health and economic burden worldwide due to the diseases that they cause. A better understanding of parasite genomes, host–parasite relationships and the molecular biology of parasites themselves will enable the rational development of diagnostic tests and/or safe anti-parasitic compounds, following the functional annotation of parasite genomic sequences. With only a few completely sequenced nematode genomes, expressed sequence tag (EST) datasets provide a low-cost alternative (“poor man's genome”) to whole genome sequences and a glimpse of the transcriptome of an organism. EST data require a number of computational methods for their pre-processing, clustering, assembly and annotation to yield biologically relevant information. In this article, we review the steps involved in EST data analysis, the development of new semi-automated bioinformatic pipelines and their application to parasitic nematodes of major socio-economic significance, focused on identifying molecules involved in key biological processes or pathways that might serve as targets for new drugs or vaccines.

Keywords
Helminths; Nematodes; Strongylida; Genomics; Transcriptomics; Bioinformatics; Drug targets
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Advanced in silico analysis of expressed sequence tag (EST) data for parasitic nematodes of major socio-economic importance — Fundamental insights toward biotechnological outcomes
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 27, Issue 4, July–August 2009, Pages 439–448
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us