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Ion channels in key marine invertebrates; their diversity and potential for applications in biotechnology

Paper ID Volume ID Publish Year Pages File Format Full-Text
14518 1226 2011 11 PDF Available
Title
Ion channels in key marine invertebrates; their diversity and potential for applications in biotechnology
Abstract

Of the intra-membrane proteins, the class that comprises voltage and ligand-gated ion channels represents the major substrate whereby signals pass between and within cells in all organisms. It has been presumed that vertebrate and particularly mammalian ion channels represent the apex of evolutionary complexity and diversity and much effort has been focused on understanding their function. However, the recent availability of cheap high throughput genome sequencing has massively broadened and deepened the quality of information across phylogeny and is radically changing this view. Here we review current knowledge on such channels in key marine invertebrates where physiological evidence is backed up by molecular sequences and expression/functional studies. As marine invertebrates represent a much greater range of phyla than terrestrial vertebrates and invertebrates together, we argue that these animals represent a highly divergent, though relatively underused source of channel novelty. As ion channels are exquisitely selective sensors for voltage and ligands, their potential and actual applications in biotechnology are manifold.

Keywords
Receptors; Ion channels; Ligand gated; Voltage-gated; Neurotransmitter receptors; Vertebrates and invertebrates
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Ion channels in key marine invertebrates; their diversity and potential for applications in biotechnology
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 29, Issue 5, September–October 2011, Pages 457–467
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us