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Antimicrobial peptides from marine invertebrates: Challenges and perspectives in marine antimicrobial peptide discovery

Paper ID Volume ID Publish Year Pages File Format Full-Text
14523 1226 2011 12 PDF Available
Title
Antimicrobial peptides from marine invertebrates: Challenges and perspectives in marine antimicrobial peptide discovery
Abstract

The emergence of pathogenic bacteria resistance to conventional antibiotics calls for an increased focus on the purification and characterization of antimicrobials with new mechanisms of actions. Antimicrobial peptides are promising candidates, because their initial interaction with microbes is through binding to lipids. The interference with such a fundamental cell structure is assumed to hamper resistance development. In the present review we discuss antimicrobial peptides isolated from marine invertebrates, emphasizing the isolation and activity of these natural antibiotics. The marine environment is relatively poorly explored in terms of potential pharmaceuticals, and it contains a tremendous species diversity which evolved in close proximity to microorganisms. As invertebrates rely purely on innate immunity, including antimicrobial peptides, to combat infectious agents, it is believed that immune effectors from these animals are efficient and rapid inhibitors of microbial growth.

Keywords
Biotechnology; Bioprospecting; Salt tolerant; Purification; Crustacea; Tunicata; Mollusca
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Antimicrobial peptides from marine invertebrates: Challenges and perspectives in marine antimicrobial peptide discovery
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 29, Issue 5, September–October 2011, Pages 519–530
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us