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GH11 xylanases: Structure/function/properties relationships and applications

Paper ID Volume ID Publish Year Pages File Format Full-Text
14533 1227 2012 29 PDF Available
Title
GH11 xylanases: Structure/function/properties relationships and applications
Abstract

For technical, environmental and economical reasons, industrial demands for process-fitted enzymes have evolved drastically in the last decade. Therefore, continuous efforts are made in order to get insights into enzyme structure/function relationships to create improved biocatalysts. Xylanases are hemicellulolytic enzymes, which are responsible for the degradation of the heteroxylans constituting the lignocellulosic plant cell wall. Due to their variety, xylanases have been classified in glycoside hydrolase families GH5, GH8, GH10, GH11, GH30 and GH43 in the CAZy database. In this review, we focus on GH11 family, which is one of the best characterized GH families with bacterial and fungal members considered as true xylanases compared to the other families because of their high substrate specificity. Based on an exhaustive analysis of the sequences and 3D structures available so far, in relation with biochemical properties, we assess biochemical aspects of GH11 xylanases: structure, catalytic machinery, focus on their “thumb” loop of major importance in catalytic efficiency and substrate selectivity, inhibition, stability to pH and temperature. GH11 xylanases have for a long time been used as biotechnological tools in various industrial applications and represent in addition promising candidates for future other uses.

Keywords
AX, arabinoxylan; BCX, Bacillus circulans GH11 xylanase; CBD, cellulose-binding domain; CBM, carbohydrate binding module; CD, catalytic domain; Cel-12, GH12 cellulase; DP, degree of polymerization; GH, glycoside hydrolase; HX, heteroxylan; MW, molecular w
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GH11 xylanases: Structure/function/properties relationships and applications
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 30, Issue 3, May–June 2012, Pages 564–592
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us