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Prospects for translational regenerative medicine

Paper ID Volume ID Publish Year Pages File Format Full-Text
14540 1227 2012 15 PDF Available
Title
Prospects for translational regenerative medicine
Abstract

Translational medicine is an evolutional concept that encompasses the rapid translation of basic research for use in clinical disease diagnosis, prevention and treatment. It follows the idea “from bench to bedside and back”, and hence relies on cooperation between laboratory research and clinical care. In the past decade, translational medicine has received unprecedented attention from scientists and clinicians and its fundamental principles have penetrated throughout biomedicine, offering a sign post that guides modern medical research toward a patient-centered focus. Translational regenerative medicine is still in its infancy, and significant basic research investment has not yet achieved satisfactory clinical outcomes for patients. In particular, there are many challenges associated with the use of cell- and tissue-based products for clinical therapies. This review summarizes the transformation and global progress in translational medicine over the past decade. The current obstacles and opportunities in translational regenerative medicine are outlined in the context of stem cell therapy and tissue engineering for the safe and effective regeneration of functional tissue. This review highlights the requirement for multi-disciplinary and inter-disciplinary cooperation to ensure the development of the best possible regenerative therapies within the shortest timeframe possible for the greatest patient benefit.

Keywords
Translational medicine; Regenerative medicine; Stem cell therapy; Tissue engineering; Regenerative dentistry; Clinical translation
First Page Preview
Prospects for translational regenerative medicine
Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 30, Issue 3, May–June 2012, Pages 658–672
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering