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Exploiting microRNAs for cell engineering and therapy

Paper ID Volume ID Publish Year Pages File Format Full-Text
14546 1227 2012 13 PDF Available
Title
Exploiting microRNAs for cell engineering and therapy
Abstract

MicroRNAs (miRNAs) form a large class of non-coding RNAs that function in repression of gene expression in eukaryotes. By recognizing short stretches of nucleotides within the untranslated regions of mRNAs, miRNAs recruit partner proteins to individual transcripts, leading to mRNA cleavage or hindering of translation. Bioinformatic predictions and a wealth of data from wet laboratory studies indicate that miRNAs control expression of a large proportion of protein-coding genes, implying involvement of miRNAs in regulation of most biologic processes. In this review we discuss the biology of miRNAs and present examples of how manipulation of miRNA expression or activity can be exploited to attain the desired phenotypic traits in cell engineering as well as achieve therapeutic outcomes in treatment of a diverse set of diseases.

Keywords
ES cells, embryonic cells; iPS cells, induced pluripotent stem cells; miRNP, microribonucleoprotein; MRE, microRNA recognition element; RISC, RNA-induced silencing complex; SIRT1, sirtuin-1; UTR, untranslated region of mRNAMicroRNA; Biogenesis; Function;
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 30, Issue 3, May–June 2012, Pages 753–765
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us