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Longer action means better drug: Tuning up protein therapeutics

Paper ID Volume ID Publish Year Pages File Format Full-Text
14554 1228 2011 6 PDF Available
Title
Longer action means better drug: Tuning up protein therapeutics
Abstract

An increasing number of proteins are currently available on the market as therapeutics and this branch of the pharmaceutical industry will expand substantially during the coming years. As many diseases result from dysfunction of proteins forming multicomponent complexes, protein drugs with their inherent high specificity and affinity seem to be optimal medical agents. On the other hand, proteins are often highly instable and sensitive to degradation, which questions their applicability as effective therapeutics. Therefore, redesign and engineering of proteins is usually a required step in the present day drug development.Several approaches have been applied to optimize the protein properties central to their pharmaceutical use. This review focuses on different strategies that improve two crucial factors influencing protein drug efficiency: protein stability and its in vivo half-life. We provide examples of successful genetic and chemical modifications applied in the design of effective protein therapeutics.

Keywords
IL-2, interleukin 2; IFN-β, interferon β; G-CSF, granulocyte colony-stimulating factor; PAL, phenylalanine ammonia lyase; hGH, human growth hormone; FGF1, fibroblast growth factor 1; apoA–I, apolipoprotein A–I; HDL, high-density lipoprotein; hTSH, human t
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 29, Issue 4, July–August 2011, Pages 436–441
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us