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Organic solvent adaptation of Gram positive bacteria: Applications and biotechnological potentials

Paper ID Volume ID Publish Year Pages File Format Full-Text
14555 1228 2011 11 PDF Available
Title
Organic solvent adaptation of Gram positive bacteria: Applications and biotechnological potentials
Abstract

Organic-solvent-tolerant bacteria are considered extremophiles with different tolerance levels that change among species and strains, but also depend on the inherent toxicity of the solvent. Extensive studies to understand the mechanisms of organic solvent tolerance have been done in Gram-negative bacteria. On the contrary, the information on the solvent tolerance mechanisms in Gram-positive bacteria remains scarce. Possible shared mechanisms among Gram-(−) and Gram-(+) microorganisms include: energy-dependent active efflux pumps that export toxic organic solvents to the external medium; cis-to-trans isomerization of unsaturated membrane fatty acids and modifications in the membrane phospholipid headgroups; formation of vesicles loaded with toxic compounds; and changes in the biosynthesis rate of phospholipids to accelerate repair processes. However, additional physiological responses of Gram-(+) bacteria to organic solvents seem to be specific. The aim of the present work is to review the state of the art of responsible mechanisms for organic solvent tolerance in Gram-positive bacteria, and their industrial and environmental biotechnology potential.

Keywords
Solvent-tolerant; Gram positive; Solvent stress; Solvent deactivation; Biocatalysis; Solvent efflux pumps; Whole-cell biocatalysis
First Page Preview
Organic solvent adaptation of Gram positive bacteria: Applications and biotechnological potentials
Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 29, Issue 4, July–August 2011, Pages 442–452
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering