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RNA interference: The story of gene silencing in plants and humans

Paper ID Volume ID Publish Year Pages File Format Full-Text
14565 1230 2008 8 PDF Available
Title
RNA interference: The story of gene silencing in plants and humans
Abstract

RNA interference is an exciting field of functional genomics that can silence viral genes. This property of interfering RNA can be used to combat viral diseases of plants as well as animals and humans. It is a short sequence of nucleic acid that can bind to the mRNA of the gene and interferes the process of its expression. It is diverse in occurrence as well as in applications. It occurs from nematodes to fungi and can cause gene silencing in plants, animals and human beings. Small interfering RNAs are used to silence plant viral genes and in production of therapeutic drugs against Hepatitis or Immuno-deficiency viruses in human. In this review, we will discuss the history, mechanism and applications of RNA interference in plant, animal and human research.

Keywords
RNA, Ribonucleic Acid; RNAi, RNA Interference; dsRNA, Double Stranded RNA; ssRNA, Single Stranded RNA; siRNA, Small Interfering RNA; RISC, RNA Induced Silencing Complex; PTGS, Post Transcriptional Gene Silencing; HCV, Hepatitis C virus; HIV, Human Immuno-
First Page Preview
RNA interference: The story of gene silencing in plants and humans
Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 26, Issue 3, May–June 2008, Pages 202–209
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering