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Recombinant human transferrin: Beyond iron binding and transport

Paper ID Volume ID Publish Year Pages File Format Full-Text
14576 1231 2011 9 PDF Available
Title
Recombinant human transferrin: Beyond iron binding and transport
Abstract

Iron is indispensible for life and essential for such processes as oxygen transport, electron transfer and DNA synthesis. Transferrin (Tf) is a ubiquitous protein with a central role in iron transport and metabolism. There is evidence, however, that Tf has many other biological roles in addition to its primary function of facilitating iron transport and metabolism, such as its profound effect on mammalian cell growth and productivity. The multiple functions of Tf can be exploited to develop many novel applications. Indeed, over the past several years, considerable efforts have been directed towards exploring human serum Tf (hTf), especially the use of recombinant native hTf and recombinant Tf fusion proteins, for various applications within biotechnology and medicine. Here, we review some of the remarkable progress that has been made towards the application of hTf in these diverse areas and discuss some of the exciting future prospects for hTf.

Keywords
Transferrin; Iron-binding protein; Multi-tasking protein; Biotechnological and medical application; Serum-free medium supplement; Disease management; Novel therapy; Novel drug delivery and targeting system; Recombinant production; Fusion protein technolog
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 29, Issue 2, March–April 2011, Pages 230–238
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us