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Cell growth and cell cycle in Saccharomyces cerevisiae: Basic regulatory design and protein–protein interaction network

Paper ID Volume ID Publish Year Pages File Format Full-Text
14586 1232 2012 21 PDF Available
Title
Cell growth and cell cycle in Saccharomyces cerevisiae: Basic regulatory design and protein–protein interaction network
Abstract

In this review we summarize the major connections between cell growth and cell cycle in the model eukaryote Saccharomyces cerevisiae. In S. cerevisiae regulation of cell cycle progression is achieved predominantly during a narrow interval in the late G1 phase known as START (Pringle and Hartwell, 1981). At START a yeast cell integrates environmental and internal signals (such as nutrient availability, presence of pheromone, attainment of a critical size, status of the metabolic machinery) and decides whether to enter a new cell cycle or to undertake an alternative developmental program. Several signaling pathways, that act to connect the nutritional status to cellular actions, are briefly outlined. A Growth & Cycle interaction network has been manually curated. More than one fifth of the edges within the Growth & Cycle network connect Growth and Cycle proteins, indicating a strong interconnection between the processes of cell growth and cell cycle. The backbone of the Growth & Cycle network is composed of middle-degree nodes suggesting that it shares some properties with HOT networks.The development of multi-scale modeling and simulation analysis will help to elucidate relevant central features of growth and cycle as well as to identify their system-level properties. Confident collaborative efforts involving different expertises will allow to construct consensus, integrated models effectively linking the processes of cell growth and cell cycle, ultimately contributing to shed more light also on diseases in which an altered proliferation ability is observed, such as cancer.

Keywords
AMPK, AMP-activated kinase; APC, Anaphase Promoting Complex; CK2, Casein Kinase 2; Cdk1, Cyclin-Dependent Kinase 1 (Cdc28); FEAR, Cdc Fourteen Early Anaphase Release; MDT, Mass Duplication Time; MEN, Mitotic Exit Network; PKA, Protein Kinase A; MBF, MCB B
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Cell growth and cell cycle in Saccharomyces cerevisiae: Basic regulatory design and protein–protein interaction network
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 30, Issue 1, January–February 2012, Pages 52–72
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us