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Systems biology of the metabolic network regulated by the Akt pathway

Paper ID Volume ID Publish Year Pages File Format Full-Text
14590 1232 2012 11 PDF Available
Title
Systems biology of the metabolic network regulated by the Akt pathway
Abstract

Cancer has been proposed as an example of systems biology disease or network disease. Accordingly, tumor cells differ from their normal counterparts more in terms of intracellular network dynamics than single markers. Here we shall focus on a recently recognized hallmark of cancer, the deregulation of cellular energetics. The constitutive activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway has been confirmed as an essential step toward cell transformation. We will consider how the effects of Akt activation are connected with cell metabolism; more precisely, we will review existing metabolic models and discuss the current knowledge available to construct a kinetic model of the most relevant metabolic processes regulated by the PI3K/Akt pathway. The model will enable a systems biology approach to predict the metabolic targets that may inhibit cell growth under hyper activation of Akt.

Keywords
ACC, acetyl-CoA carboxylase; ACCOA, acetyl-CoA; ACD, acyl-CoA dehydrogenase; ACL, ATP citrate lyase; ACS, acyl-CoA synthetase; ADP, adenosine diphosphate; ALD, fructose 1,6 bisphosphate aldolase; AMP, adenosine monophosphate; ATP, adenosine triphosphate;
First Page Preview
Systems biology of the metabolic network regulated by the Akt pathway
Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 30, Issue 1, January–February 2012, Pages 131–141
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering