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Atypical (RIO) protein kinases from Haemonchus contortus — Promise as new targets for nematocidal drugs

Paper ID Volume ID Publish Year Pages File Format Full-Text
14618 1233 2011 13 PDF Available
Title
Atypical (RIO) protein kinases from Haemonchus contortus — Promise as new targets for nematocidal drugs
Abstract

Almost nothing is known about atypical kinases in multicellular organisms, including parasites. Supported by information and data available for the free-living nematode, Caenorhabditis elegans, and other eukaryotes, the present article describes three RIO kinase genes, riok-1, riok-2 and riok-3, from Haemonchus contortus, one of the most important parasitic nematodes of small ruminants. Analyses of these genes and their products predict that they each play critical roles in the developmental pathways of parasitic nematodes. The findings of this review indicate prospects for functional studies of these genes in C. elegans (as a surrogate) and opportunities for the design of a novel class of nematode-specific inhibitors of RIO kinases. The latter aspect is of paramount importance, given the serious problems linked to anthelmintic resistance in parasitic nematode populations of livestock.

Keywords
Parasite; Haemonchus contortus; RIO kinases; Structure; Relationships; Inferred function; Drug targets
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Atypical (RIO) protein kinases from Haemonchus contortus — Promise as new targets for nematocidal drugs
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 29, Issue 3, May–June 2011, Pages 338–350
Authors
, , , , , , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us