fulltext.study @t Gmail

Genetic engineering of filamentous fungi — Progress, obstacles and future trends

Paper ID Volume ID Publish Year Pages File Format Full-Text
14634 1235 2008 9 PDF Available
Title
Genetic engineering of filamentous fungi — Progress, obstacles and future trends
Abstract

Filamentous fungi are widely used in biotechnology as cell factories for the production of chemicals, pharmaceuticals and enzymes. In order to improve their productivities, genetic engineering strategies can be powerful approaches. Different transformation techniques as well as DNA- and RNA-based methods to rationally design metabolic fluxes have been developed for industrially important filamentous fungi. However, the lack of efficient genetic engineering approaches still forms an obstacle for a multitude of fungi producing new and commercially interesting metabolites. This review summarises the variety of options that have recently become available to introduce and control gene expression in filamentous fungi and discusses their advantages and disadvantages. Furthermore, important considerations that have to be taken into account to design the best engineering strategy will be discussed.

Keywords
Filamentous fungi; Genetic and metabolic engineering; Transformation; Gene targeting; ku70; Antisense; RNAi; Hammerhead ribozyme
First Page Preview
Genetic engineering of filamentous fungi — Progress, obstacles and future trends
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 26, Issue 2, March–April 2008, Pages 177–185
Authors
,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us