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The production of biopharmaceuticals in plant systems

Paper ID Volume ID Publish Year Pages File Format Full-Text
14659 1237 2009 16 PDF Available
Title
The production of biopharmaceuticals in plant systems
Abstract

Biopharmaceuticals present the fastest growing segment in the pharmaceutical industry, with an ever widening scope of applications. Whole plants as well as contained plant cell culture systems are being explored for their potential as cheap, safe, and scalable production hosts. The first plant-derived biopharmaceuticals have now reached the clinic. Many biopharmaceuticals are glycoproteins; as the Golgi N-glycosylation machinery of plants differs from the mammalian machinery, the N-glycoforms introduced on plant-produced proteins need to be taken into consideration. Potent systems have been developed to change the plant N-glycoforms to a desired or even superior form compared to the native mammalian N-glycoforms. This review describes the current status of biopharmaceutical production in plants for industrial applications. The recent advances and tools which have been utilized to generate glycoengineered plants are also summarized and compared with the relevant mammalian systems whenever applicable.

Keywords
ADCC, antibody dependent cellular cytotoxicity; BHK cells, baby hamster kidney cells; CHO cell, Chinese hamster ovary cell; EPO, erythropoietin; ER, endoplasmid reticulumn; Fuc, fucose; FucT, fucosyltransferase; Gal, galactose; GalNAc, N-acetylgalactosami
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 27, Issue 6, November–December 2009, Pages 879–894
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
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