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Systems biology of the cell cycle of Saccharomyces cerevisiae: From network mining to system-level properties

Paper ID Volume ID Publish Year Pages File Format Full-Text
14666 1237 2009 19 PDF Available
Title
Systems biology of the cell cycle of Saccharomyces cerevisiae: From network mining to system-level properties
Abstract

Following a brief description of the operational procedures of systems biology (SB), the cell cycle of budding yeast is discussed as a successful example of a top-down SB analysis. After the reconstruction of the steps that have led to the identification of a sizer plus timer network in the G1 to S transition, it is shown that basic functions of the cell cycle (the setting of the critical cell size and the accuracy of DNA replication) are system-level properties, detected only by integrating molecular analysis with modelling and simulation of their underlying networks. A detailed network structure of a second relevant regulatory step of the cell cycle, the exit from mitosis, derived from extensive data mining, is constructed and discussed.To reach a quantitative understanding of how nutrients control, through signalling, metabolism and transcription, cell growth and cycle is a very relevant aim of SB. Since we know that about 900 gene products are required for cell cycle execution and control in budding yeast, it is quite clear that a purely systematic approach would require too much time. Therefore lines for a modular SB approach, which prioritises molecular and computational investigations for faster cell cycle understanding, are proposed.The relevance of the insight coming from the cell cycle SB studies in developing a new framework for tackling very complex biological processes, such as cancer and aging, is discussed.

Keywords
APC, Anaphase Promoting Complex; Cdk1, Cyclin dependent kinase1 (Cdc28); CK2, Casein Kinase 2; FEAR, Cdc Fourteen Early Anaphase Release; GAP, GTPase activating protein; GEF, Guanine Exchange Factor; MBF, MCB, MluI Cell Cycle Box, Binding Factor; MCC, Mit
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 27, Issue 6, November–December 2009, Pages 960–978
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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