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Tobacco, a highly efficient green bioreactor for production of therapeutic proteins

Paper ID Volume ID Publish Year Pages File Format Full-Text
14685 1238 2010 8 PDF Available
Title
Tobacco, a highly efficient green bioreactor for production of therapeutic proteins
Abstract

Molecular farming of pharmaceuticals in plants has the potential to provide almost unlimited amounts of recombinant proteins for use in disease diagnosis, prevention or treatment. Tobacco has been and will continue to be a major crop for molecular farming and offers several practical advantages over other crops. It produces significant leaf biomass, has high soluble protein content and is a non-food crop, minimizing the risk of food-chain contamination. This, combined with its flexibility and highly-efficient genetic transformation/regeneration, has made tobacco particularly well suited for plant-based production of biopharmaceutical products. The goal of this review is to provide an update on the use of tobacco for molecular farming of biopharmaceuticals as well the technologies developed to enhance protein production/purification/efficacy. We show that tobacco is a robust biological reactor with a multitude of applications and may hold the key to success in plant molecular farming.

Keywords
Green bioreactor; Tobacco plant; Molecular farming; Biopharmacuticals; Oral tolerance
First Page Preview
Tobacco, a highly efficient green bioreactor for production of therapeutic proteins
Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 28, Issue 2, March–April 2010, Pages 214–221
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering