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Cunninghamella – A microbial model for drug metabolism studies – A review

Paper ID Volume ID Publish Year Pages File Format Full-Text
14714 1242 2009 14 PDF Available
Title
Cunninghamella – A microbial model for drug metabolism studies – A review
Abstract

Drug metabolism studies constitute an important and necessary step in the evaluation of drug efficacy and safety. In vivo drug metabolism studies suffer from many disadvantages. Hence there is a rise in validation of in vitro microbial models. This review describes the transformation studies of drugs by the fungus, Cunninghamella and correlating them with the metabolism/biotransformation in animal systems and providing technical methods to develop microbial models. Emphasis is laid on the potential of Cunninghamella fungus to mimic mammalian drug biotransformations and to use as in vitro model for drug metabolism studies and for further toxicological and pharmacological studies of metabolites.

Keywords
Biotransformation; Cunninghamella; CYP450; Drug; In vitro metabolism study; Microbial metabolites; Microbial model; Metabolism; Metabolites
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Cunninghamella – A microbial model for drug metabolism studies – A review
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 27, Issue 1, January–February 2009, Pages 16–29
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us