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ATP in current biotechnology: Regulation, applications and perspectives

Paper ID Volume ID Publish Year Pages File Format Full-Text
14720 1242 2009 8 PDF Available
Title
ATP in current biotechnology: Regulation, applications and perspectives
Abstract

Adenosine tri-phosphate (ATP), the most important energy source for metabolic reactions and pathways, plays a vital role in the growth of industrial strain and the production of target metabolites. In this review, current advances in manipulating ATP in industrial strains, including altering NADH availability, and regulating NADH oxidation pathway, oxygen supply, proton gradient, the electron transfer chain activity and the F0F1-ATPase activity, are summarized and discussed. By applying these strategies, optimal product concentrations, yields and productivity in industrial biotechnology have been achieved. Furthermore, the mechanisms by which ATP extends the substrate utilization spectra and enhances the ability to challenge harsh environmental stress have been elucidated. Finally, three critical issues related to ATP manipulation have been addressed.

Keywords
ATP synthase; Metabolic engineering; Cofactor engineering; Biotechnology process optimization; Energy metabolism
First Page Preview
ATP in current biotechnology: Regulation, applications and perspectives
Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 27, Issue 1, January–February 2009, Pages 94–101
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering