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Designing culture surfaces based on cell anchoring mechanisms to regulate cell morphologies and functions

Paper ID Volume ID Publish Year Pages File Format Full-Text
14754 1246 2010 10 PDF Available
Title
Designing culture surfaces based on cell anchoring mechanisms to regulate cell morphologies and functions
Abstract

This review article presents an outlook on the current strategies and existing concepts for culture surface designs to regulate cell morphologies and functions. First, cell structures and cell attachment behaviors are described in relation to the interactions between cells and their surroundings. Next, various surface designs are addressed, with a summary of the current topics of particular interest. The architectural features of substrates can be controlled to facilitate the quest for design principles including material choices and geometric modifications. In addition, various types of biomolecules, such as adhesive elements and growth factors, can be incorporated to regulate cell behaviors, including cell attachment, growth and differentiation. It is possible to manipulate these surface variables to produce desired surface designs for inducing cellular responses. In the latter part of this article, the topics discussed involve dendrimer-immobilized surfaces designed in authors' studies dealing with the in vitro culture processes of differentiated and undifferentiated cells. This article will offer novel insights into the processing of cells and tissues toward therapeutic applications in regenerative medicine.

Keywords
Tissue engineering; Culture surface design; Glucose transporter-mediated anchoring; Dendrimer surface; Cellular morphology; Aggregate formation; Signal transduction
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 28, Issue 1, January–February 2010, Pages 7–16
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us