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Elucidating ANTs in worms using genomic and bioinformatic tools — Biotechnological prospects? ☆

Paper ID Volume ID Publish Year Pages File Format Full-Text
14758 1246 2010 12 PDF Available
Title
Elucidating ANTs in worms using genomic and bioinformatic tools — Biotechnological prospects? ☆
Abstract

Adenine nucleotide translocators (ANTs) belong to the mitochondrial carrier family (MCF) of proteins. ATP production and consumption are tightly linked to ANTs, the kinetics of which have been proposed to play a key regulatory role in mitochondrial oxidative phosphorylation. ANTs are also recognized as a central component of the mitochondrial permeability transition pore associated with apoptosis. Although ANTs have been investigated in a range of vertebrates, including human, mouse and cattle, and invertebrates, such as Drosophila melanogaster (vinegar fly), Saccharomyces cerevisiae (yeast) and Caenorhabditis elegans (free-living nematode), there has been a void of information on these molecules for parasitic nematodes of socio-economic importance. Exploring ANTs in nematodes has the potential lead to a better understanding of their fundamental roles in key biological pathways and might provide an avenue for the identification of targets for the rational design of nematocidal drugs. In the present article, we describe the discovery of an ANT from Haemonchus contortus (one of the most economically important parasitic nematodes of sheep and goats), conduct a comparative analysis of key ANTs and their genes (particularly ant-1.1) in nematodes and other organisms, predict the functional roles utilizing a combined genomic-bioinformatic approach and propose ANTs and associated molecules as possible drug targets, with the potential for biotechnological outcomes.

Keywords
ANT, adenine nucleotide translocator; dsRNA, double-stranded RNA; EST, expressed sequence tag; L2, second-stage larva; L3, third-stage larva; L4, fourth-stage larva; RACE, rapid amplification of cDNA ends; qPCR, quantitative PCR; RNAi, double-stranded RNA
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Elucidating ANTs in worms using genomic and bioinformatic tools — Biotechnological prospects? ☆
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 28, Issue 1, January–February 2010, Pages 49–60
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us