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Sustainable biocatalytic synthesis of L-homophenylalanine as pharmaceutical drug precursor

Paper ID Volume ID Publish Year Pages File Format Full-Text
14787 1250 2009 11 PDF Available
Title
Sustainable biocatalytic synthesis of L-homophenylalanine as pharmaceutical drug precursor
Abstract

Over the past decade, L-homophenylalanine is extensively used in the pharmaceutical industry as a precursor for production of angiotensin-converting enzyme (ACE) inhibitor, which possesses significant clinical application in the management of hypertension and congestive heart failure (CHF). A number of chemical methods have been reported thus far for the synthesis of L-homophenylalanine. However, chemical methods generally suffer from process complexity, high cost, and environmental pollution. On the other hand, enantiomerically pure L-homophenylalanine can be obtained elegantly and efficiently by employing biocatalytic methods, where it appears to be the most attractive process in terms of potential industrial applications, green chemistry and sustainability. Herein we review the biocatalytic synthesis of vital L-homophenylalanine as potentially useful intermediate in the production of pharmaceutical drugs in environmentally friendly conditions, using membrane bioreactor for sustainable biotransformation process. One envisages the future prospects of developing an integrated membrane bioreactor system with improved performance for L-homophenylalanine production.

Keywords
L-homophenylalanine; Pharmaceuticals; ACE inhibitor; Drug precursor; Membrane bioreactor; Biocatalysis
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Sustainable biocatalytic synthesis of L-homophenylalanine as pharmaceutical drug precursor
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 27, Issue 3, May–June 2009, Pages 286–296
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us